MTW European Type Trapezium Mill
Input size:30-50mm
Capacity: 3-50t/h
LM Vertical Roller Mill
Input size:38-65mm
Capacity: 13-70t/h
Raymond Mill
Input size:20-30mm
Capacity: 0.8-9.5t/h
Sand powder vertical mill
Input size:30-55mm
Capacity: 30-900t/h
LUM series superfine vertical roller grinding mill
Input size:10-20mm
Capacity: 5-18t/h
MW Micro Powder Mill
Input size:≤20mm
Capacity: 0.5-12t/h
LM Vertical Slag Mill
Input size:38-65mm
Capacity: 7-100t/h
LM Vertical Coal Mill
Input size:≤50mm
Capacity: 5-100t/h
TGM Trapezium Mill
Input size:25-40mm
Capacity: 3-36t/h
MB5X Pendulum Roller Grinding Mill
Input size:25-55mm
Capacity: 4-100t/h
Straight-Through Centrifugal Mill
Input size:30-40mm
Capacity: 15-45t/h
Model parameters of Epo
A Biomathematical Model of Human Erythropoiesis under
2013年6月6日 Parameters of our model were determined by a stepwise fitting procedure First, pharmacokinetic and dynamic parameters (PD) of EPO and parameters of the cell kinetic 2013年6月6日 Unknown model parameters were determined by fitting the predictions of the model to data sets of circulating erythrocytes, haemoglobin, (PDF) A Biomathematical Model of Human 2023年12月5日 Erythropoietin (EPO) is a key endogenous protein which increases the number of erythrocyte progenitors that mature into red blood cells that carry hemoglobin (Hb) Recombinant human erythropoietin (rHuEPO) in Frontiers Quantitative systems pharmacology model 2024年1月8日 We suggest that EPO may control RBC lifespan by determining CD47 expression in newly formed RBCs and SIRP α expression in sinusoidal macrophages EPO could also A new role for erythropoietin in the homeostasis of red blood cells
Pharmacokinetic and pharmacodynamic modeling of recombinant
2005年11月1日 Erythropoietin (EPO), a natural glycoprotein hormone, is synthesized predominantly in the kidneys in response to tissue hypoxia EPO stimulates production of 2020年9月29日 We utilized a Bayesian approach and informative priors to characterize HGB profiles, using simulated drug concentrations, in patients with end‐stage renal disease Population Pharmacodynamic Modeling of Epoetin Alfa in 2013年6月6日 Unknown model parameters were determined by fitting the predictions of the model to data sets of circulating erythrocytes, haemoglobin, haematocrit, percentage of A biomathematical model of human erythropoiesis under2019年10月19日 Based on a model of erythropoiesis we formulate a nonlinear model predictive control (NMPC) algorithm for the individualized optimization of epoetin alfa (EPO) doses Optimal EPO dosing in hemodialysis patients using a nonlinear
Population pharmacodynamic analysis of
A population pharmacokinetics/pharmacodynamic (PK/PD) model was developed to describe changes in erythropoiesis as a function of plasma erythropoietin (EPO) concentration over the first 30 days of 2021年3月1日 The material model parameters of the composite were determined through coupon level tests and the calibrations between model and experiments In addition to the commonly used test methods, the doubleshear and Brazilian tests were applied to determine the throughthickness shear modulus and tensile strength, respectivelyDetermination of the material model and damage parameters of Previous to this work, model parameters were estimated for individual patients using clinical data The optimal control problem is formulated for a continuous drug administration This is currently a hypothetical form of drug administration for EPO as it would require a programmable EPO pump similar to insulin pumps used to treat patients with diabetes mellitusOptimal EPO dosing in hemodialysis patients using a nonlinear model 2020年11月1日 Model Parameters are properties of training data that will learn during the learning process, in the case of deep learning is weight and bias Parameter is often used as a measure of how well a What Are Model Parameters In Deep Learning, and
A simple but effective evaluation criterion for parameters
2023年5月15日 The Regression Toolbox for MATLAB was used to calibrate the PLS model EPO, LOCAL and LOCAL combined with spiking methods were implemented using custom codes, which are available from the authors 4 Results and discussion The reason for this phenomenon may be that when optimizing EPO parameters with RMSECV evaluation As indicated above, the model parameters were determined by fitting the model to the experimental data drawn from BarreroVillar et al 2009 [10] (see Figure 3)Structure of the JAK2STAT5 pathway model proposed Legend: Epo 2009年2月4日 Kurzke, J "Model Based Gas Turbine Parameter Corrections" Proceedings of the ASME Turbo Expo 2003, collocated with the 2003 International Joint Power Generation Conference Volume 1: Turbo Expo 2003 Atlanta, Georgia, Model Based Gas Turbine Parameter Corrections2013年6月6日 Parameters of our model were determined by a stepwise fitting procedure First, pharmacokinetic and dynamic parameters (PD) of EPO and parameters of the cell kinetic model were estimated by comparing the predictions of the model with available time series data after application of EPO into healthy volunteersA Biomathematical Model of Human Erythropoiesis under Erythropoietin
A mouse model for an erythropoietindeficiency anemia
2010年10月28日 In mammals, the production of red blood cells is tightly regulated by the growth factor erythropoietin (EPO) Mice lacking a functional Epo gene are embryonic lethal, and studying erythropoiesis in EPOdeficient adult animals has therefore been limited In order to obtain a preclinical model for an EPOdeficient anemia, we developed a mouse in which Epo can be 2003年6月1日 Request PDF EPO–PLS external parameter orthogonalisation of PLS application to temperatureindependent measurement of sugar content of intact fruits Near Infrared (NIR) spectrometry would EPO–PLS external parameter orthogonalisation of PLS application 2006年8月20日 @article{Trummer2006ProcessPS, title={Process parameter shifting: Part I Effect of DOT, pH, and temperature on the performance of Epo‐Fc expressing CHO cells cultivated in controlled batch bioreactors}, author={Evelyn Trummer and Katharina Fauland and Silke Seidinger and Kornelia Schriebl and Christine Lattenmayer and Renate Kunert and Process parameter shifting: Part I Effect of DOT, pH, and Structure of the model of erythropoiesis under chemotherapy and EPO application We combined four independently developed models (cell kinetic, pharmacokinetic, injection, chemotherapy) into one Structure of the model of erythropoiesis under
Summary of Model Parameters • parameters Pages
The modelparameters() function (also accessible via the shortcut parameters()) allows you to extract the parameters and their characteristics from various models in a consistent wayIt can be considered as a lightweight alternative to broom::tidy(), with some notable differences: The names of the returned data frame are specific to their content For instance, the column 2019年12月1日 Previous to this work, model parameters were estimated for individual patients using clinical data The optimal control problem is formulated for a continuous drug administrationOptimal EPO dosing in hemodialysis patients using Schematic diagram of the quantitative systems pharmacology model to examine hyporesponsiveness to rHuEPO treatment in rats Model parameters and abbreviations are described in “Appendix 1” (Abbreviations) Three solid red boxes represent processes in the bone marrow, spleen, and bloodA quantitative systems pharmacology model of hyporesponsiveness to Whereas external parameters are well controlled in routine laboratories, they can vary greatly in industrial conditions and alter the measured spectra From a mathematical point of view, if the model is linear and if the external parameter level is stable during the test, a bias appears in the predicted valuesEPO–PLS external parameter orthogonalisation of PLS application
Comparative Performance of Cell Life Span and Cell Transit Models
2011年10月18日 The individual post hoc PK parameters from the model were used to predict the individual concentrations, which were then used to describe the erythropoietic effects of the EPO mimetic via a cell life span or a transit model The PK parameters from the final population PK model are provided in Table I2021年8月19日 Example 3 Erythropoietin (Epo) and Epo receptor (EpoR) interaction and trafficking (\(M3\)) We now analyse a realworld systems biology model In erythroid progenitor cells, which give rise to Assessing the role of initial conditions in the local structural To study the effects of EPO in AD mouse models via a noninvasive transvascular route of administration, an MTHEPO fusion protein was engineered using a rat/mouse chimeric antibody directed Pharmacokinetics Parameters of cTfRMAbEPO in the Mouse aHyperparameters¶ Hyperparameters are adjustable parameters that let you control the model optimization process Different hyperparameter values can impact model training and convergence rates (read more about hyperparameter tuning)We define the following hyperparameters for training:Optimizing Model Parameters — PyTorch Tutorials 250+cu124
EPOPLS external parameter orthogonalisation of PLS application
13 EPO : A method to reduce the space dimensionality with regard to external parameters The method proposed here, External Parameter Orthogonalisation (EPO), deals with the case where the external parameter can not be measured online Spectra are preprocessed by projection onto the orthogonalto the space2019年10月19日 First insilico results of this framework are presented in this paper Based on a model of erythropoiesis we formulate a nonlinear model predictive control (NMPC) algorithm for the individualized optimization of epoetin alfa (EPO) doses Previous to this work, model parameters were estimated for individual patients using clinical dataOptimal EPO dosing in hemodialysis patients using a nonlinear model 2023年11月29日 After using EPO, the levels of these parameters decreased significantly in the diabetic+EPO group compared to the diabetic control group Based on the results, In this study, the influence of evening primrose oil on the serum levels of omentin1 and some of biochemical parameters in the diabetic rat model were investigatedAssessing evening primrose oil effects on the serum levels of 2014年11月3日 In the rest, two equivalent circuit models, the firstorder resistancecapacitance (RC) model and the secondorder RC model, were investigated for a lithiumion battery The GaussNewton (GN) least square was applied to identify the two model parameters because of its nonlinear estimation and iteration The lithiumion battery rested respectively at three SOC A comparative study on RC models of lithiumion battery
Optimal EPO dosing in hemodialysis patients using a nonlinear model
(EPO) doses Previous to this work, model parameters were estimated for individual patients using clinical data The optimal control problem is formulated for a continuous drug administration This is currently a hypothetical form of drug administration for EPO as it would require a programmable EPO pump similar to insulin pumpsM( ;p) ygis the set of parameters corresponding to models that produce the worst percentile of returns, and provides the limit for the integral; M( ;P) is the random variable of returns, which is induced by the distribution over model parameters; and is a hyperparameterEPO : L ROBUST NEURAL NETWORK P U MODEL ENSEMBLESLess Complex Model Faster Parameter Estimation 95% of accuracy in tuning parameters Effective capturing of nonlinear effects No manual tuning of parameters required for validation Battery Plant model Plant model with the estimated parameters are used in the HIL test bench 75% 95% 80% methods, y System identification Lsq curve fit fminconBattery Parameter Estimation MATLAB EXPOThe EPO has just completely revised its Guidelines for sections 33 to 332), which especially apply to simulations, designs, models and artificial The revised EPO Guidelines also again remind that a technical nature of the data or parameters used for a mathematical method does not necessarily imply that the mathematical The Patenting of Mathematical Methods at the EPO
EP B1 DETERMINING MODEL PARAMETERS
The model parameter determiner is configured to determine an updated set of model parameters on the basis of the regionrelated similarity measure and an optimization scheme[origin: WOA1] Apparatus for determining model parameters, the apparatus comprising an object model transformer, a region comparator, and a model parameter determiner2020年5月25日 Unknown model parameters were determined by fitting the predictions of the model to time series data from literature We demonstrate how the model can be used to make predictions of untested therapy options such as cytotoxic chemotherapy supported by A biomathematical model of human erythropoiesis and iron2018年4月18日 Model parameters Model parameters were estimated on a persubject basis during the adaptation period using each patient’s individual recordings The adjusted model parameters, such as RBC lifespan and endogenous EPO production show a remarkable alignment with previously reported values in clinical studies in HD patients Prediction of hemoglobin levels in individual hemodialysis patients • Foundation of the model is diet data from early 1990s EPO has experienced some of the strongest El Nino events on record FAD impacts may have altered predatorprey dynamics • EPO ecological sampling program required to update diet matrix and key model parameters (eg consumption rates, SAC10 INFE)Ecosystem model of the EPO progress report
T 1614/08 (Simulation model/Entelos) 11072011 epo
2011年7月11日 assigning, via a graphical user interface, values to object parameters (70, 72) of objects (54) of a simulation model (30) in accordance with any preceding claim; and utilizing the values assigned to the object parameters as initial input values for object parameters (70, 72) in the simulation model (30)"2022年8月12日 In this section, we search for the optimal initial parameters of the AH, ADW, EPO, and HK models using the parameter calibration method in the framework For the initial observation, we set a combination of parameters Dynamic Parameter Calibration Framework for 2022年3月8日 Visible and nearinfrared (Vis–NIR) spectroscopy can provide a rapid and inexpensive estimation for soil organic carbon (SOC) However, with respect to field in situ spectroscopy, external environmental factors likely degrade the model accuracy Among these factors, moisture has the greatest effect on soil spectra The external parameter Comparing Two Different Development Methods of External Parameter 2020年5月24日 Data Sources and Data Analysis for System Parameters A systematic literature search was performed using PubMed to screen for agedependency of physiologic parameters required to construct the paediatric PBPK model for TPs using the keywords ‘neonates’, ‘newborn’, ‘infants’, ‘children’ and ‘paediatric’ (and ‘pediatric’) plus the system parameter of interestDevelopment and Application of a PhysiologicallyBased
The epidemiology ontology: an ontology for the semantic
2014年1月17日 The first version of EPO models several epidemiology and demography parameters as well as transmission of infection processes, participants and related procedures It currently has nearly 200 classes and is designed to support the semantic annotation of epidemiology resources and data integration, as well as information retrieval and knowledge 2013年6月3日 Erythropoietin regulates erythropoiesis in a hypoxiainducible manner Here we generate inherited superanaemic mice (ISAM) as a mouse model of adultonset anaemia caused by erythropoietin deficiencyA mouse model of adultonset anaemia due to erythropoietin EP B1 METHOD FOR ESTIMATING PARAMETER OF EQUIVALENT CIRCUIT MODEL FOR BATTERY, AND BATTERY MANAGEMENT SYSTEM [origin: USA1] Disclosed is a method and a battery management system for estimating the parameters of an equivalent circuit model for a battery The equivalent circuit EP B1 METHOD FOR ESTIMATING PARAMETER 2019年10月1日 Although we were unable to include the endogenous production rate of Epo in the model, we do not expect the PK parameters to be significantly affected since this study used large doses of Epo, 600 U/kg and 1200 U/kg, and the resulting Epo plasma concentrations were up to three orders of magnitude higher than the endogenous Epo level which averaged 883 TargetMediated Disposition Population Pharmacokinetics Model
Population pharmacodynamic analysis of erythropoiesis in
The Hb mass balance model fit along with plasma EPO concentration and body weight for three representative subjects are shown in Fig 2 The model captures the general behavior of the Hb and RBC concentration data The pharmacodynamic model parameters are summarized in